Custom Peptides
Cayman Chemical Milbemycin oxime, Purity: ≥95%, CAS: 129496-10-2, 10 mg
A semisynthetic macrocyclic lactone prepared by the oxidation and oximation of an 80:20 ratio of milbemycin A3 and A4; nematocide and insecticide activity via the potentiation of glutamate and GABA-gated chloride-channel opening
Cayman Chemical fluoro-Dapagliflozin, Purity: ≥95%, CAS: 1181681-43-5, 10 mg
An analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis = 5.3 and 330 nM, respectively); significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2
Cayman Chemical Nε-(1-Carboxymethyl)-L-lysine, Purity: ≥95%, CAS: 5746-04-3, 10 mg
An AGE, produced by the oxidative modification of glycated proteins during oxidative stress; increases with aging and during pathologies marked by oxidative stress; activates RAGE, triggering signaling through MAPKs and NF-κB
Cayman Chemical QuIzartInIb 10mg
A selective FLT3 inhibitor (Kd = 1.6 nM) that inhibits the proliferation of MV4-11 cells both in vitro (IC50 = 0.56 nM) and in in vivo mouse models of FLT3-ITD acute myeloid leukemia
Cayman Chemical 15(S)-Fluprostenol, Purity: ≥98%, CAS: 54276-24-3, 10 mg
An isomer of fluprostenol; a potential active metabolite to 15(S)-fluprostenol isopropyl ester
Cayman Chemical Tasquinimod, Purity: ≥98%, CAS: 254964-60-8, 10 mg
An orally-active quinoline-3-carboxamide that inhibits tumor angiogenesis and supplements radiation or chemotherapy in animal models of prostate cancer
Cayman Chemical Evernic Acid, Purity: ≥98%, CAS: 537-09-7, 10 mg
A secondary metabolite produced by some species of lichen that binds FAS-II enzymes to produce antibacterial and antiplasmodial effects; inhibits PfFabZ and PfFabI (IC50 = 10.7 and 36.1 µM, respectively) but shows low efficacy against the malaria parasite P. berghei (IC50 = 77.3 µM)
Cayman Chemical 4-hydroxy-3-Methoxyphenylglycol (piperazine salt), Purity: ≥98%, CAS: 67423-45-4, 10 mg
A metabolite of norepinephrine used as a biochemical index of recent sympathetic nervous system activity
Cayman Chemical Niguldipine (hydrochloride), Purity: ≥98%, CAS: 119934-51-9, 10 mg
A dihydropyridine that acts as a potent, selective α1A-adrenoceptor antagonist (Ki = 0.16 nM); less potently blocks L- and T-type Ca2+ channels (IC50s = 0.4 and 0.9 µM, respectively)
Cayman Chemical SIN-1 (chloride), Purity: ≥99%, CAS: 16142-27-1, 10 mg
Active metabolite of molsidomine that acts as a potent vasorelaxant and inhibitor of platelet aggregation; produces both NO and superoxide to generate peroxynitrite under physiological conditions
Cayman Chemical L-NIL (hydrochloride), Purity: ≥95%, CAS: 159190-45-1, 10 mg
A relatively selective inhibitor of iNOS, exhibiting IC50 values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively; effectively inhibits iNOS both in vitro and in vivo
Cayman Chemical DETA NONOate, Purity: ≥95%, CAS: 146724-94-9, 10 mg
DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Cayman Chemical TrImethoprImPEGamIntrIfl 10mg
A conjugated form of trimethoprim linked with polyethylene glycol (PEG) amine
Cayman Chemical Decanoyl m-Nitroaniline, Purity: ≥98%, CAS: 72298-61-4, 10 mg
One of several nitroaniline fatty acid amides that can be used to measure FAAH activity; exposure to FAAH results in the release of the yellow colorimetric dye m-nitroaniline (ε = 13,500 at 410 nm) allowing for fast and convenient measurement of FAAH activity using a 96-well plate spectrophotometer
Cayman Chemical Vinyl-L-NIO (hydrochloride), Purity: ≥95%, CAS: 728944-69-2, 10 mg
A potent, selective inhibitor of nNOS with Ki values for inhibition of nNOS, eNOS and iNOS of 100 nM, 12 µM and 60 µM, respectively